SYRE HealthcareBeta data

Spyre Therapeutics, Inc.

$99.27+3.94%

Price as of close on Nov 3, 2026 · Financials updated Oct 1, 2026

Basics

Sector: Healthcare
Industry: Biotechnology
Country: United States
Market cap: 8.8B USD
Enterprise value: 7.8B USD
Full-time employees: 125

Overall health

Strength: lower risk than most peers: more short-term liquiditylower risk: more liquidity
Drawback: less profitable than most peersless profitable than peers
Drawback: its shares are priced higher than most peers relative to what it earnspriced higher than peers for its earnings
Drawback: its share price swings more than most peers’ (beta 3.00 vs a peer median of 0.63)bigger price swings (beta 3.00 vs peers 0.63)
Not enough data: growth

Would rank #625 of 1,157 fully scored healthcare companies (bottom 47%)

Partial overall score — 3/4 categories available.

See how it ranks against its peers

Worth knowing

Valuation signals disagree. Cheaper than 50% of peers on free cash flow, but only 0% on earnings.
Relative to its free cash flow, Spyre Therapeutics looks cheaper than 50% of peers; relative to its earnings, cheaper than only 0%. The valuation score blends the two, so look at which measure fits this business best.
Not profitable yet. Reported a loss over the last 12 months.
Spyre Therapeutics reported a net loss over the last twelve months, so earnings-based measures can't show it as cheap.
More volatile share price. Beta 3.00: tends to move more than the market.
Spyre Therapeutics's shares have swung more with the market than most peers' (beta 3.00, above the market's 1.0).

StockQuotient Score

50/ 100

Oct 5 51 → Nov 4 50 (-1)

Fundamentals: Yahoo Finance, not primary filings

Valuation

Is the price right?

33/100

Weak

2/3 inputs reported · Partial data

Since last year: ▼ Weaker

Share count up 13.6% (existing holders diluted)

Valuation also moves with the share price every day.

Why

Weaker than most peers on:

▼ Earnings yield

Compare with peers

Behind the score

Sector-normalized EBITDA, earnings, and free cash flow yields.

Earnings yield-1.9%

Yahoo Finance · trailing 12 monthsNegative (a loss or cash outflow), so it counts as zero whatever the share price30% base weight · Z-score -1.00Sector median: 0.0148 · MAD: 0.0148

EBITDA yieldUnavailable

Missing · left out of the score · no sector data, so not countedNot counted · remaining weights rescaledSector median: 0.0401 · MAD: 0.0401

Free cash flow yield-2.4%

Yahoo Finance · trailing 12 months · operating cash flow − capital spendingNegative (a loss or cash outflow), so it counts as zero whatever the share price20% base weight · Z-score 0.00Sector median: 0.0000 · MAD: 0.0000

Other data (not scored)

Book yield10.9%

Yahoo FinanceReported valueInformational · 0% composite weightSector median: 0.3716 · MAD: 0.2313

Growth

Is it growing?

Insufficient data

Insufficient data: 0 of 3 inputs reported (at least 2 needed). We leave it blank rather than fill the gap with a made-up middle value.

Profitability

Does it earn well?

24/100

Weak

2/3 inputs reported · Partial data

Since last year: No major change

Why

Weaker than most peers on:

▼ ROA
▼ ROIC

Compare with peers

Behind the score

Return on invested capital, operating margin, and return on assets.

Operating marginUnavailable

Missing · left out of the score · no sector data, so not countedNot counted · remaining weights rescaledSector median: 0.0706 · MAD: 0.1217

Return on assets-15.3%

SEC filings · 12 months to Jun 2026Reported value33% base weight · Z-score -3.15Sector median: 0.0166 · MAD: 0.0537

Return on invested capital-16.9%

SEC filings · 12 months to Jun 2026Reported value33% base weight · Z-score -2.16Sector median: 0.0471 · MAD: 0.1004

Other data (not scored)

Gross margin0.0%

Yahoo Finance · trailing 12 monthsReported valueInformational · 0% composite weightSector median: 0.4697 · MAD: 0.2310

Return on equity-23.0%

Yahoo Finance · trailing 12 monthsReported valueInformational · 0% composite weightSector median: 0.0330 · MAD: 0.1225

Risk

Debt, liquidity, price swings

Lower

Lower relative risk

2/3 inputs reported · Partial data

Since last year: No major change

Why

Stronger than most peers on:

▲ Current ratio

Compare with peers

Behind the score

Relative to sector peers: 0 = lower relative risk · 1 = moderate · 2 = higher. Based on leverage, beta and liquidity.

Beta3.00

Yahoo Finance · 5-year monthly beta vs the marketOutlier capped at sector 5th/95th percentile33% base weight · Z-score -4.28Sector median: 0.6250 · MAD: 0.3380

Current ratio18.53×

Yahoo FinanceOutlier capped at sector 5th/95th percentile33% base weight · Z-score 11.07Sector median: 2.5860 · MAD: 1.3850

Debt / equityUnavailable

Missing · left out of the score · no sector data, so not countedNot counted · remaining weights rescaledSector median: 0.2215 · MAD: 0.2039

Valuation, growth and profitability scores: higher is better. Risk: 0 is lower, 2 is higher. Risk is a relative proxy, not a bankruptcy probability. Scores depend on available sector peers.

Questions investors ask about Spyre Therapeutics

Is Spyre Therapeutics getting weaker?: Its latest SEC filing (Aug 4, 2026) got weaker in some ways: share count up 13.6%. Its overall score is unchanged at 50/100 since Oct 28, 2026.
How is Spyre Therapeutics valued vs its peers?: Priced higher than most peers relative to what it earns. Valuation scores 33/100 against 1,393 healthcare peers. Earnings yield -1.9% vs a peer median of 1.5% (weaker than 100% of peers).Earnings yield -1.9% vs peers 1.5% (weaker than 100% of peers).
Is Spyre Therapeutics growing?: Insufficient data: 0 of 3 inputs reported (at least 2 needed).
How profitable is Spyre Therapeutics?: Less profitable than most of its peers. Profitability scores 24/100 against 1,393 healthcare peers. Return on assets -15.3% vs a peer median of 1.7% (weaker than 78% of peers).Return on assets -15.3% vs peers 1.7% (weaker than 78% of peers).
How risky is Spyre Therapeutics?: Lower risk relative to 1,393 healthcare peers, judged on debt, liquidity and share-price swings. Current ratio 18.53× vs a peer median of 2.59× (stronger than 95% of peers).Current ratio 18.53× vs peers 2.59× (stronger than 95% of peers). Beta 3.00 vs a peer median of 0.63 (weaker than 100% of peers).Beta 3.00 vs peers 0.63 (weaker than 100% of peers). A relative measure, not a bankruptcy probability.

Latest filing: what changed

Year ended Dec 31, 2025 · filed Aug 4, 2026 · compared with the year ended Dec 31, 2024

Got weaker

Share count up 13.6% (existing holders diluted)

	Previous year	Latest year	Change
Revenue (12 months)	0 USD	0 USD	—
Net income (12 months)	−149.0M USD	−178.9M USD	+20.1%
Cash	64.9M USD	162.0M USD	+149.6%
Shares outstanding	77.6M	88.2M	+13.6%

From the company’s own SEC filings, as filed. Twelve-month figures roll forward one year at a time.

Industry valuation context

Industry: Biotechnology · 132 companies

Valuations in Biotechnology are within their usual range since 2016.

48% of months since 2016 were valued lower than now.
22% of companies are in the most expensive fifth of their own price-to-sales history.
Median price-to-sales is +530% vs the whole market, against a usual +637%.

2016Shaded: most expensive fifth of its range2026

Earnings-based measures are left out for now because many companies in Biotechnology are losing money.

Financials

Fiscal years from SEC annual filings · change vs the prior year

Key ratios	FY 2021	FY 2022	FY 2023	FY 2024	FY 2025	Change
Operating margin	-350.3%	-3640.2%	-27348.0%	—	—	—
Net margin	-351.1%	-3598.8%	-38238.1%	—	—	—
Return on assets (ROA)	-59.9%	-117.8%	-99.1%	-34.2%	-20.0%	▲ 14 pts
Return on equity (ROE)	-78.4%	-166.6%	-184.1%	-40.2%	-21.7%	▲ 18 pts
Free cash flow margin	-289.7%	-3442.8%	-11276.5%	—	—	—
Current ratio	4.91×	4.25×	10.68×	11.26×	13.25×	▲ 18%

SYRE price history

Price history is added with the daily price update and will appear after the next one.

Similar companies

Sector leaderboards

BB Biotech AGBBZA.DE100/ 100

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Bringing the fundamentals into focus…

Overall health

Strength: lower risk than most peers: more short-term liquiditylower risk: more liquidity

Drawback: less profitable than most peersless profitable than peers

Drawback: its shares are priced higher than most peers relative to what it earnspriced higher than peers for its earnings

Drawback: its share price swings more than most peers’ (beta 3.00 vs a peer median of 0.63)bigger price swings (beta 3.00 vs peers 0.63)

Not enough data: growth

Would rank #625 of 1,157 fully scored healthcare companies (bottom 47%)

Partial overall score — 3/4 categories available.

See how it ranks against its peers

Worth knowing

Valuation signals disagree. Cheaper than 50% of peers on free cash flow, but only 0% on earnings.

Relative to its free cash flow, Spyre Therapeutics looks cheaper than 50% of peers; relative to its earnings, cheaper than only 0%. The valuation score blends the two, so look at which measure fits this business best.

Not profitable yet. Reported a loss over the last 12 months.

Spyre Therapeutics reported a net loss over the last twelve months, so earnings-based measures can't show it as cheap.

More volatile share price. Beta 3.00: tends to move more than the market.

Spyre Therapeutics's shares have swung more with the market than most peers' (beta 3.00, above the market's 1.0).

Questions investors ask about Spyre Therapeutics

Is Spyre Therapeutics getting weaker?

Its latest SEC filing (Aug 4, 2026) got weaker in some ways: share count up 13.6%. Its overall score is unchanged at 50/100 since Oct 28, 2026.

How is Spyre Therapeutics valued vs its peers?

Priced higher than most peers relative to what it earns. Valuation scores 33/100 against 1,393 healthcare peers. Earnings yield -1.9% vs a peer median of 1.5% (weaker than 100% of peers).Earnings yield -1.9% vs peers 1.5% (weaker than 100% of peers).

Is Spyre Therapeutics growing?

Insufficient data: 0 of 3 inputs reported (at least 2 needed).

How profitable is Spyre Therapeutics?

Less profitable than most of its peers. Profitability scores 24/100 against 1,393 healthcare peers. Return on assets -15.3% vs a peer median of 1.7% (weaker than 78% of peers).Return on assets -15.3% vs peers 1.7% (weaker than 78% of peers).

How risky is Spyre Therapeutics?

Lower risk relative to 1,393 healthcare peers, judged on debt, liquidity and share-price swings. Current ratio 18.53× vs a peer median of 2.59× (stronger than 95% of peers).Current ratio 18.53× vs peers 2.59× (stronger than 95% of peers). Beta 3.00 vs a peer median of 0.63 (weaker than 100% of peers).Beta 3.00 vs peers 0.63 (weaker than 100% of peers). A relative measure, not a bankruptcy probability.

Previous year

Latest year

Change

Revenue (12 months)

0 USD

0 USD

—

Net income (12 months)

−149.0M USD

−178.9M USD

+20.1%

Cash

64.9M USD

162.0M USD

+149.6%

Shares outstanding

77.6M

88.2M

+13.6%

Key ratios

FY 2021

FY 2022

FY 2023

FY 2024

FY 2025

Change

Operating margin

-350.3%

-3640.2%

-27348.0%

—

Net margin

-351.1%

-3598.8%

-38238.1%

—

Return on assets (ROA)

-59.9%

-117.8%

-99.1%

-34.2%

-20.0%

▲ 14 pts

Return on equity (ROE)

-78.4%

-166.6%

-184.1%

-40.2%

-21.7%

▲ 18 pts

Free cash flow margin

-289.7%

-3442.8%

-11276.5%

—

Current ratio

4.91×

4.25×

10.68×

11.26×

13.25×

▲ 18%